Pair Name	Lycorine hydrochloride, Anti-CTLA-4
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Biological Phenomena	Inhibition-->Immune checkpoint
Gene Regulation	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CCND3	hsa896
	Down-regulation	Expression	CDK2	hsa1017
In Vitro Model	Caki-1	Clear cell renal cell carcinoma	Homo sapiens (Human)	CVCL_0234
	ACHN	Papillary renal cell carcinoma	Homo sapiens (Human)	CVCL_1067
	KPK1	Renal cell carcinoma	Homo sapiens (Human)	CVCL_F947
	RenCa	Mouse kidney carcinoma	Mus musculus (Mouse)	CVCL_2174
In Vivo Model	Renca-Luc cells were inoculated into the sub-renal capsule kidney (3×10⁵ cells in 50 μl PBS) and tail vein (2×10⁵ cells in 30 μl PBS) of C57BL/6 mice to produce an orthotopic tumor and metastatic lung tumors.
Result	Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma